The most common manifestation of HSV infection is sores which may. The purpose of this investigation is to assess the prevalence of infectious disease seropositivity toxoplasmosis, rubella, cytomegalovirus [CMV] , herpes simplex virus type 1 HSV -1 and.
This phase I study will be conducted in HSV -seropositive subjects with advanced primary liver cancer that are refractory to. It will be protected with a passcode Generate session link. Access your activity on CenterWatch with a private link and passcode. Share Passcode: Copy to clipboard. Please select a valid location from the dropdown. Filter By Clear all Advanced. Male only 2 Female only 3 Any Reset Apply. I am looking for. I am looking for acyclovir. Eligibility Criteria.
Inclusion Criteria: Males and females. Females must be postmenopausal defined as 12 consecutive months without menstruation. Patients that test equivocal index between 0. If the results are negative at the second test, the patient will not enter the study. If the results are equivocal or positive at the second test first test was equivocal , we will enroll the patient in the study because "equivocal" indicates the presence of antibodies that do not reach the minimum threshold.
Use of cholinesterase inhibitors and memantine, and concomitant psychotropic medications other than high dose benzodiazepines , will be permitted throughout the trial. Doses of these medications will need to be stable for at least 1 month prior to study entry. Any changes to the medication will be documented in the participant research chart. Medications given for other medical reasons, e. Details of concomitant medication use will be documented at all visits and will be available for statistical analysis.
Physical Evaluation Exclusion Criteria: Caregiver is unwilling or unable, in the opinion of the investigator, to comply with study instructions. Physician Evaluation Patient has dementia predominantly of non-Alzheimer's type, including vascular dementia, frontotemporal dementia, Lewy body dementia, substance-induced dementia.
Physician Evaluation Modified Hachinski scale score greater than 4. Physician Evaluation Current clinical diagnosis of schizophrenia, schizoaffective disorder, other psychosis, bipolar disorder or current major depression by DSM-5 criteria. Physician Evaluation Active suicidal intent or plan based on clinical assessment.
Physician Evaluation Current or recent past 6 months alcohol or substance use disorder DSM-5 criteria. Physician Evaluation Current diagnosis of other major neurological disorders, including Parkinson's disease, multiple sclerosis, CNS infection, Huntington's disease, and amyotrophic lateral sclerosis. Physician Evaluation Clinical stroke with residual neurological deficits.
MRI findings of cerebrovascular disease small infarcts, lacunes, periventricular disease in the absence of clinical stroke with residual neurological deficits will not lead to exclusion. Physician Evaluation Acute, severe, unstable medical illness. For cancer, patients with active illness or metastases in the last 12 months will be excluded, but past history of successfully treated cancer will not lead to exclusion.
Physician Evaluation Use of benzodiazepines in lorazepam equivalent doses equal to or greater than 2 mg daily. This will be determined through study staff i. Principal Investigator, Study Physician discussion with potential subjects at Screening, documenting inquiry about radiation history.
If there is any history of additional radiation exposure in the past year; it will be reviewed with PET Center staff for their approval before proceeding. J Clin Microbiol. Development of a high-throughput quantitative assay for detecting herpes simplex virus DNA in clinical samples. Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. Once-daily valacyclovir to reduce the risk of transmission of genital herpes.
Crumpacker CS. Use of antiviral drugs to prevent herpesvirus transmission. Acetylsalicylic acid reduces viral shedding induced by thermal stress. Curr Eye Res. New indications. FDA Drug Approvals , Sheskin DJ. Handbook of Parametric and Nonparametric tatistical Procedures. National Library of Medicine U.
National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Herpes Simplex. We study millions of patients and 5, more each day. Our analysis results are available to researchers, health care professionals, patients testimonials , and software developers open API.
All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
0コメント